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Just to catch anyone up who is unfamiliar with the term GLP-1 agonist, this term refers to a class of medications that all act on the GLP-1 receptor
Ipamorelin is a synthetic five-amino-acid peptide (a pentapeptide) that selectively switches on the ghrelin receptor - one of the body's signals for releasing growth hormone
Semaglutide and tirzepatide share similar side effects, but studies show that semaglutide can cause higher rates of vomiting, constipation, and fatigue
The synergy occurs because each medication addresses a distinct defect in glucose homeostasis
The vascular endothelium, a critical regulator of vascular tone, becomes dysfunctional when excessive ROS impairs nitric oxide (NO) bioavailability, a hallmark of HTN